Friday, April 29, 2022

How and why optimizing your body’s immune

How and why optimizing your body’s immune system for preventing and treating Cancer?

Many may be wondering how exactly the immune system and cancer are interrelated. It’s quite complex given that it has taken decades of countless scientific research in search of a cure. The goal is to break this cancer into its basic mechanisms to fully understand its totality and appreciate its processes.

In general, the immune system works by fighting against any harmful substances such as bacteria, fungi, viruses, and cancer cells. Something important to note is that your own cells and immune system can and will betray you.

It could be easier to think of our cells as a double-sided sword. Take, for instance, antigen-presenting cells, specifically dendritic cells which act by collecting information and delivering it to the immune system. Whenever bad information is delivered it will cause the immune system to slow down, depleting the body’s overall vitality. As we can see, this dual-action a single cell can produce can either help or hurt the process. This is just one of the many examples that occur within the body with other cells.

Thankfully, there are different forms of therapy such as cryoablation which works by attacking such cells which cause harm to the body. Adjuvants are another tool that serves the positive stimulation of immune response. They are substances that can be injected into and around the ablated tumor.

But before jumping into these therapies, it’s recommended to strengthen the immune system in healthy ways to promote higher chances of immunotherapy to be effective in treating certain cancers.

However, due to the complexity of the immune response and regulatory cells it contains for autoimmunity protection, it is crucial to understand that these cells act like a double-sided sword. On its dark side, regulatory cells can be attacked by cancer and will serve as anti-cancer immune response blockers.

Overall, finding ways to optimize one’s immune system can be tedious in midst of so much chaos with busy work schedules, relationships, and currently dealing with a pandemic. Below is a compiled list of suggestions for boosting the immune system with the hope of preventing and/or curing cancer.

  • Vitamin D (sun exposure or supplement in conjunction with Vit. K)
  • Vitamin C (through diet or supplement)
  • Minimum of 30 minutes of physical activity (can be a light jog, yoga, pilates, Zumba, weight lifting, etc)
  • Healthy balanced diet according to body constitution
  • Consuming healthy fats such as fish oil or flaxseed oil to decrease inflammation
  • Limiting sugar intake
  • Receiving adequate sleep
  • Being outdoors in nature more often

The material contained on this site is for informational purposes only and DOES NOT CONSTITUTE THE PROVIDING OF MEDICAL ADVICE, and is not intended to be a substitute for independent professional medical judgment, advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare providers with any questions or concerns you may have regarding your health.

The post How and why optimizing your body’s immune appeared first on Williams Cancer Institute.



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Wednesday, April 27, 2022

Pentoxifylline an FDA Approved

Pentoxifylline an FDA Approved Drug for Vascular Disease That May Boost Immunotherapy

Pentoxifylline, sold under the brand name Trental is typically used for vascular disease to increase blood flow due to its effect in reducing blood viscosity.  However, there is a gene called c-Rel that is important to maintain the function of regulatory cells such as Tregs and MDSC.  As I have discussed, the immune system has two sides, one that is regulatory, which has been tricked by cancer to protect it.  There is the other side that can attack cancer.

Our goal is to tip the balance in favor of attacking cancer.   In a study published by Grinberg-Bleyer, et al in Cell, Sept 7, 2017, titled “NF-kB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer” they describe how blocking c-Rel can reduce the regulatory function of Tregs.  In addition, Li, et al published in Nature Cancer, May 18, 2020, an article titled “c-Rel is a Myeloid Checkpoint for Cancer Immunotherapy” which discusses MDSC.

These two articles are describing how c-Rel is key to two of the main groups of immune cells that can inhibit an anti-cancer immune response.  In turn, blocking c-Rel was demonstrated in animals to enhance standard immunotherapy, such as PD-1 inhibitors.  Blocking both c-Rel and PD-1 together was better than either alone.  The study by Grinberg-Bleyer showed that Pentoxifylline, a c-Rel inhibitor delayed tumor growth in the mouse model.  When administered with a PD-1 inhibitor, the effects of both were enhanced.  Though there are other c-Rel inhibitors in development, since Pentoxifylline is available and FDA approved, it may allow for off-label use which could improve the results of immunotherapy.

Jason R. Williams, MD, DABR

The material contained on this site is for informational purposes only and DOES NOT CONSTITUTE THE PROVIDING OF MEDICAL ADVICE, and is not intended to be a substitute for independent professional medical judgment, advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare providers with any questions or concerns you may have regarding your health.

The post Pentoxifylline an FDA Approved appeared first on Williams Cancer Institute.



source https://williamscancerinstitute.com/pentoxifylline-an-fda-approved/?utm_source=rss&utm_medium=rss&utm_campaign=pentoxifylline-an-fda-approved