Friday, July 22, 2022

Do you know the hidden health benefits of Green Tea?

Do you know the hidden health benefits of Green Tea?





Green tea isn’t only one of the most popular drinks in the UK but in the world for centuries, and many people barely know its benefits. But how much do you know about the hidden benefits? Researchers have found that green tea comes from a plant called Camellia sinensis L, native to northern India and southern China; this plant has innumerable benefits for our health. For example, it contains an antioxidant called polyphenols, which fight free radicals in the body and can even cause cell death.

According to ecaner.org, Green Tea has too many benefits that you might never know about, such as preventing aging or increasing metabolism. Isn’t that great? And here is more; It boosts weight loss, reduces stress and anxiety, has relaxing effects, and improves mental focus and concentration (Yes to mental health); worried about chronic diseases? Keep reading; it also prevents infections, has anti-cancer effects, is an excellent neuroprotector, reduces cardiovascular disease, prevents Alzheimer’s, helps control diabetes, and works as an antidiarrheal.

However, there is no clear evidence that tea prevents cancer. Still, several studies have shown that tea can prevent the growth of cancerous tumors, especially for breast cancer in its early stages, working as the self-destruction of cancer cells., said breastcancer.org.

Many oncologists recommend drinking 3 to 4 cups daily, positively affecting the outcomes of the treatments and boosting the well-being of the patients. Did you know anything of these facts mentioned in this article? I know it might be mind-blowing, but I felt the same writing this article; now, don’t wait to start adding more cups to your diet and enjoy it with a nice view while giving happiness to your body.


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Wednesday, July 20, 2022

The Effect of Traditional Cancer Treatments On the Cancer Immune Response—The Good, The Bad and The Ugly

INTRATUMORAL IMMUNOTHERAPY AND CRYOABLATION FOR CANCER – WELCOME TO Cabo San Lucas, Mexico.

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Monday, July 18, 2022

Intra-tumoral injection of vaccines, viruses and vaccine adjuvants

Intra-tumoral injection of vaccines, viruses and vaccine adjuvants





There are numerous techniques to stimulate an immune response into a tumor. It has been noted that in certain cases vaccines intended to prevent other illness may inadvertently stimulate an immune response within cancer. Myers, et al. published in March 2005 an article “Oncolytic activities of approved mumps and measles vaccines for therapy of ovarian cancer.” They state: “In this study we demonstrated that two commercially available paramyxoviral vaccines, Moraten measles and Jeryl Lynn mumps have promising anti-tumor activities against human ovarian xenografts established in the peritoneal cavities of immunodeficient mice.” Galanis, et al., also from Mayo, published January 2015 in Cancer Res that the use of the Edmonston vaccine strain of the measles virus showed effectiveness in the treatment of ovarian cancer, in patients who had previously received extensive chemotherapy, extending survival to 26.5 months in a group of 16 patients. Msaouel, et al., also from Mayo, reported anti-tumor activity with the same Edmonston measles vaccine. I might add that this is the old version of the measles vaccine.
Curiously, about the time of some of these publications, these vaccines have become hard to find, and it seems their sale in the U.S. has been blocked, as now everything has shifted to the use of the MMR in place of the older vaccine. I won’t speculate the coincidence of the timing of this. As you see from the study, the results are not perfect, but I am sure the success can be increased with the combined use of other immunotherapy agents.
In July of 2018, Mckenzie and Nichols published in JAMA Dermatology a study in which a 97-year old woman with squamous cell carcinoma of the skin was treated successfully with a series of injections of Gardasil, the HPV vaccine. They initially injected the patient in the arm, to initiate an immune reaction, and then followed up with injection into the tumor. They noted that non-treated lesions resolved as well. There are numerous viruses or viral-based gene therapies that can be injected into tumor and can stimulate an immune response. Like most treatments, the use of these alone is probably not enough to generate a cure in most patients, but this can probably be significantly improved when used with the right combination of immunotherapy agents.
It is also reasonable to mention that, just like in vaccines, for the combination of immunotherapy agents to be effective, they often need a carrier agent, known as a vaccine adjuvant. This can be a key aspect to generating an immune response. In our work, we use Montanide ISA 51 or Saponin-based vaccine adjuvants, sometimes with a gel delivery. The idea is not only to enhance antigen delivery to the immune cells, but also to create a slow release formulation, keeping the medicines in the tumor environment. Montanide ISA 51 is used in several vaccines as an adjuvant because it is a water and oil-based mixture that enhances antigen delivery. It seems that the oil can solubilize some of the medications and create a slow release delivery system.
Another promising intra-tumoral therapy involves the use of a gene therapy that causes the increased production of Interleukin 12 within the tumor. IL-12 can activate both natural killer cells (NK) and attacking (cytotoxic) T cells. Studies are being done to inject the gene in a plasmid within the tumor. In addition, the gene can be placed within a virus and injected into the tumor. In this case, both the virus itself and the increase in production of IL-12 can stimulate an immune response against the cancer.


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Interview with Jack Canfield and Dr. Jason R. Williams

Interview with Jack Canfield and Dr. Jason R. Williams




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Sunday, July 17, 2022

INTRATUMORAL IMMUNOTHERAPY AND CRYOABLATION FOR CANCER

INTRATUMORAL IMMUNOTHERAPY AND CRYOABLATION FOR CANCER




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Wednesday, July 13, 2022

INTRATUMORAL IMMUNOTHERAPY AND CRYOABLATION FOR CANCER

INTRATUMORAL IMMUNOTHERAPY AND CRYOABLATION FOR CANCER




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Tuesday, July 12, 2022

TURMERIC AND ITS PROPERTIES

TURMERIC AND ITS PROPERTIES





Turmeric is a herbaceous plant from India whose scientific name is Curcuma longa. This plant contains various human benefits and can be used to prepare numerous dishes. Still, it is primarily used for natural medicinal effects since it contains curcuminoids. such as: curcumin, demethoxycurcumin and bisdemethoxycurcumin. We must also highlight that turmeric contains other compounds such as vitamin C, E, and K, iron, and zinc, which makes this species special.

Likewise, turmeric is a natural medicament used to alleviate different affections in humans such as stomachache, loss of appetite, liver disorders, inflammation, cardiovascular diseases, reduced allergies, depression, or reverse cognitive deterioration. In addition, turmeric is being used in treating cancer patients since it contains at least ten protective anticancer components against various types of cancer.

Nowadays, there are many presentations through which we can find turmeric or curcumin, such as extracts, tablets, capsules, and many more with which we can begin to use it and learn about its innumerable benefits. Still, we must also know that the absorption in the body of this plant is a bit hard, so it is recommended to take it together with olive oil and black pepper to achieve a more significant effect.

Even though turmeric contains properties that help calm ailments and treat certain chronic diseases in humans, scientists around the world continue to investigate how far this plant can help in the cure of cancerous diseases because research carried out in laboratories shows that curcumin inhibits carcinogenesis and the proliferation of tumor cells in animals. However, it is not confident whether curcumin has the same effect on people. Therefore, it is recommended that patients with cancer take this product much more often, especially if they are undergoing any cancer treatment.

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Sunday, July 10, 2022

Sounding The Alarm Bells: Critical Information for all Cancer Immunotherapy Patients, Acetaminophen Drastically Reduces Response to Immunotherapy

Sounding The Alarm Bells: Critical Information for all Cancer Immunotherapy Patients, Acetaminophen Drastically Reduces Response to Immunotherapy



When it comes to cancer immunotherapy, there are lots of discoveries.  In some cases, some significantly impact the potential for treatment success.  In the past, we have seen where antibiotics can have tremendous negative consequences on immunotherapy success.  We have learned better the timing of this (within the first month of starting therapy) and ways that seem to help overcome it (using akkermansia and clostridium butyricum).  However, with this new data on acetaminophen, I must sound the alarm bells as this is a disastrous problem.  We typically do not recommend that our patients take acetaminophen due to liver toxicity. It also does not positively affect the immune response such as ibuprofen or aspirin.  However, this advice is often ignored by the patient and is a critical mistake.  If you are a cancer patient on immunotherapy, you must avoid acetaminophen-like the plaque.  This is vital information, and please share it with all you know.  Now let’s get to the science.

Bessede, et al. published in the “Annals of Oncology” that I read in a pre-proof journal; see reference below.  The title is “Impact of acetaminophen on the efficacy of immunotherapy in cancer patients.”   As this great group of scientists did, they reviewed human data and further confirmed with mouse studies.  The overall take-home message is that acetaminophen increases regulatory immune cells, which help protect cancer from your attacking side of the immune system. As you may recall from my book, the immune system has two sides, one that attacks cancer and one that protects it.

In cancer treatment, you want to increase the first and decrease the latter, tipping the balance in favor of cancer attacking. This study showed that acetaminophen given over 24 hours increased Treg and IL-10, both immune suppressive. They also cite previous data that acetaminophen impacts the effects of vaccines, so much so that the WHO recommended not using it close to vaccines. In addition, they saw an increase in immune-suppressive myeloid and plasmacytoid dendritic cells that were immune suppressive.  A discussion of dendritic cells always brings up dendritic cell vaccines, but remember that not all dendritic cells want to attack cancer; some are protecting it.  This is one factor that has led to their lack of success in cancer treatment.  In addition to increasing regulatory cells, acetaminophen also increases the expression of other inhibitory checkpoints such as LAG3 and TIM3.  It is essential to mention that Opdualag, approved in March, contains a LAG3 inhibitor and was one of the first new types of immunotherapy supported since 2014.

This study with acetaminophen looks at patients with renal cell carcinoma who were on Opdivo (nivolumab).  A horrifying statistic was patients with significant detectable levels of acetaminophen or related metabolites; overall survival was reduced by more than 50% (7.87 vs. 16.56 months).  One important thing to remember is that acetaminophen is added to many pain medications often used by patients with cancer.  So, it is not only taking acetaminophen itself, such as Tylenol but also what may be in pain medications, such as Lortab or Norco, to name a few. More data is needed, but unless there is no other option, it seems that acetaminophen should be avoided in cancer patients receiving immunotherapy.  As with any potential cancer treatments, discuss this with your doctor, and please share this article and the reference below.  It is essential to their other patients as well.  A good doctor is always happy to learn from their patients.

Jason R. Williams, MD, DABR

Chief of Interventional Oncology/Immunotherapy

Williams Cancer Institute

Author of “The Immunotherapy Revolution, The Best New Hope For Saving Cancer Patients’ Lives”

Bessede A, Marabelle A, Guégan J, Danlos F, Cousin S, Peyraud F, Chaput N, Spalato M, Roubaud G, Cabart M, Khettab M, Chaibi A, Rey C, Nafia I, Mahon F, Soria J, Italiano A, Impact of acetaminophen on the efficacy of immunotherapy in cancer patients., Annals of Oncology (2022), doi: https://doi.org/10.1016/j.annonc.2022.05.010.

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Thursday, July 7, 2022

Marijuana or cannabis and its medical uses

Marijuana or cannabis and its medical uses





Marijuana was originally cultivated in Central Asia and is now cultivated in many countries around the world. This plant has been analyzed by many scientists for its analgesic properties in humans, but unfortunately it has not yet been made sure this product helps treat cancer.
Like many medicines, the use of marijuana can cause serious health damage, which can lead to complications and side effects when taken.
Similarly, smoking marijuana brings harmful substances such as toxins and carcinogens to the human body, which are contained in cigarette smoke and can cause cancer, being also harmful to the lungs and cardiovascular system as well. Although more research is needed to verify the incidence of marijuana at respiratory levels in lung and other cancers. It is also known that cannabis can produce concentrated substances, including cannabinoids of which some of them are psychoactives that may affect the human mind and mood. That is why it is a plant that is still being studied due to post-consumption side effects.

On the other hand, it is said that cannabinoids such as THC and CBD are being used for medical purposes in patients with chronic diseases, but there is no evidence that they are effective in treating cancer. There are also many legal and bureaucratic barriers complicates the researching on its uses.

Even though many claim that the cancerous disease has healed after taking cannabis, until recently, there is no real evidence to prove these testimonials because most of the cancer types these people claim to had are cancers that a human can get and still live for at least 10 more years. So then stating that a person is alive after a year of cannabis use is not the desired result.

Cannabis may help with the symptoms caused by cancer, but it does not mean that it cures it. In addition, cannabis is known to be a highly complex mixture containing many compounds that can have many analgesic effects in humans, but immune responses with intratumoral injections are still being studied. Therefore, cannabis is said to be a usable product, as a palliative therapy, but not as a cure for cancerous diseases.

Studies with patients receiving intravenous immunotherapy have suggested negative effects. For this reason, we generally advise patients receiving immunotherapy to avoid cannabis products


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Cancer Procedures: Ultrasound guided breast mass cryoablation with injection of immunotherapy

Cancer Procedures: Ultrasound guided breast mass cryoablation with injection of immunotherapy




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Tuesday, July 5, 2022

AblationVax™: The Cancer Ablation “Vaccine”

AblationVax™: The Cancer Ablation “Vaccine”





We often use either Montanide ISA 51 or a hydrogel to achieve a depot effect in the tumor microenvironment. If you inject just a water-soluble drug, especially in a non-ablated tumor, much of the drug may exit the tumor microenvironment due to the increased blood flow often found with tumors, creating a wash out effect. This is less of an issue injecting into an ablated tumor, as usually the blood flow has been cut off or reduced by the ablation process. This is another advantage offered by ablation. However, I still feel it is good to use an agent that will cause a slow release and keep the medication for an extended period of time within the tumor environment.
Without going into too much detail of the science behind these findings (which you can find in the References), the basic process involves killing the tumor with cryoablation that will simultaneously stimulate the immune system, and adding vaccine adjuvants and immune checkpoint inhibitor drugs directly at the ablation site so that the typical aspects that will inhibit an effective immune response are blocked. This process creates an effective tumor “vaccine” which, while not technically a vaccine against cancer that healthy people can use to protect against cancer cells forming in the first place, does act in the same way as a vaccine for those who already have cancer cells proliferating in their bodies. The effect is not just the elimination of cancer at the ablation site, but also the stimulation of a complete response against all of that cancer cell type in the body.
Essentially, the patient’s own tumor has created a vaccine response in the body. Different than most vaccines, a vaccine made from your own tumor in your body is specific for you. It may also target numerous tumor antigens, giving the immune system antigen diversity.
This way even if a cancer tries to hide, by mutating and disguising an antigen, this technique of AblationVax™ can have multiple targets, so the cancer typically would have to hide numerous antigens at once, which is far less likely to happen.
–
Jason R Williams, MD DABR
Chief of Interventional Oncology
In order to read more you can download a free copy of my book in the following link

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How does Immunotherapy Work?

How does Immunotherapy Work?Hello




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