An isoelectric point is a common way to characterize viruses. However, it's not easy. To improve manufacturing for vaccines and gene therapy, a team uses surface charge to determine the isoelectric point of different viruses. Specifically, they use a single-particle method with atomic force microscopy (AFM).
from Health & Medicine News -- ScienceDaily https://www.sciencedaily.com/releases/2020/01/200108123135.htm
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