Opioid-containing painkillers have severe side effects and have also been associated with extensive misuse, particularly in the United States. Recent findings represent a significant step towards the development of a new generation of painkillers. Their findings show that tissue acidity - or tissue pH - at the source of the pain (i.e. injury) is a crucial determinant in the development of new drugs.
from Health & Medicine News -- ScienceDaily https://www.sciencedaily.com/releases/2020/03/200303113259.htm
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