Epigenetic changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes. These changes are responsible for the altered methylation activity of specific genes which differs from that in healthy individuals. In humans, 105 such changes have been discovered in blood cells.
from Health & Medicine News -- ScienceDaily https://www.sciencedaily.com/releases/2020/09/200910110843.htm
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